Navigating the myriads of supplements available for menopausal support can be overwhelming. Two current options that will be considered in this review are Femarelle and Relizen.
First up, neither of these made it onto our best menopause supplements breakdown, which means that we don't really recommend either. Both rely on patented ingredients, but one is a bit better than the other. Femarelle uses a soy extract, and there are more potent versions of the same extract that haven't been trademarked, but there are numerous none self funded studies that show there's some efficacy in the compounds. Relizen however, is entirely reliant on poor quality self funded studies and a customer survey to which they controlled the results.
As such we'd say you're better off getting something that uses ingredients that are backed by trials they're not connected with. If you want a quick recommendation EstroCare is infinitely better than either of these options, 20 independently studied ingredients in the doses that were used in the effective trials, and along with a money back guarantee.
That said, let's crack on with our comparison of these two supplements to help you understand their origins, mechanisms, benefits, and considerations.
What is Femarelle?
Femarelle was developed in Israel by Se-cure Pharmaceuticals, Femarelle is a non-hormonal dietary supplement designed to alleviate menopausal symptoms and support bone health.
The main active Ingredient, the primary component is DT56a, a proprietary compound derived from the fermentation of soybean (non-GMO soy).
Femarelle offers different formulations targeting specific stages:
- Femarelle Rejuvenate (Age 40+): For women in the early phases of menopause.
- Femarelle Recharge (Age 50+): For menopausal women experiencing symptoms like hot flashes and sleep disturbances.
- Femarelle Unstoppable (Age 60+): For post-menopausal women focusing on bone and vaginal health.
But ultimately they all suffer with the same issues of relying heavily on a branded soy extract. The thing is, there are none branded versions with the exact same compound make up and in fact more potent ones, so this is ultimately just a marketing trick.
Target Audience: Women who are Experiencing night sweets and hot flushes, and potentially help with weight gain associated with changes in estrogen levels.
Pros and Cons of Femarelle
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Pros |
Cons |
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Clinical studies have shown that Femarelle can significantly reduce menopausal symptoms such as hot flashes, night sweats, mood swings, and sleep disturbances. |
Contains fermented soy derivatives, meaning if you have allergies you need to avoid this. |
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Femarelle has been shown to promote bone density and reduce the risk of osteoporosis by acting on estrogen receptors in bone tissue. |
Women with certain estrogen-sensitive conditions should consult a healthcare provider before use. |
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Contains DT56a, a proprietary fermented soy extract that acts as a selective estrogen receptor modulator (SERM) without introducing synthetic hormones. |
May not be readily available in all regions or local pharmacies; sometimes requires purchasing online or through specific retailers. |
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Clinical trials indicate minimal side effects, with no significant stimulation of breast or uterine tissue. |
Some users may experience mild gastrointestinal discomfort or allergic reactions. |
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Offers tailored products (Rejuvenate, Recharge, Unstoppable) targeting specific menopausal stages and symptoms. |
Femarelle may be more expensive than other over-the-counter menopause supplements. |
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Users often report enhanced overall well-being, including better sleep quality and mood stabilization. |
Benefits may take several weeks to manifest; consistent daily intake is necessary for optimal results. |
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Does not significantly alter systemic estrogen levels, reducing risks associated with hormone therapies. |
Especially important for women with medical histories involving hormone-sensitive conditions. |
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Simplified dosing regimen with one capsule taken twice daily. |
May interact with certain medications; users should consult a healthcare provider. |
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Uses non-genetically modified soy in its formulations. |
Capsule materials or other ingredients may not be suitable for strict vegans or vegetarians. |
What makes Femarelle unique?
At the heart of Femarelle is DT56a, a proprietary compound derived from fermented, non-genetically modified soybean (Glycine max). But DT56a isn't just any soy extract. DT56a acts as a SERM, meaning it selectively binds to estrogen receptors in specific tissues. This allows Femarelle to mimic the positive effects of estrogen where it's beneficial, without stimulating tissues
where estrogen could have adverse effects. Enhances bone mineral density by activating estrogen receptors in bone tissue, reducing the risk of osteoporosis.
Overall, Benefits Femarelle.
Unlike traditional hormone replacement therapy (HRT), Femarelle offers the benefits of estrogen without the associated risks, such as increased chances of certain cancers or cardiovascular issues.
Who Should Use Femarelle?
If you're in the early stages of hormonal changes, Femarelle Rejuvenate is formulated for women around the age of 40+, addressing initial signs like decreased energy, menstrual irregularities, and skin changes. For those who prefer to avoid hormone replacement therapy (HRT) due to personal choice or medical reasons, Femarelle offers a non-hormonal option with selective estrogen receptor modulation effects
Relizen Bonafide:
What is Relizen Bonafide?
Relizen Bonafide is a non-hormonal dietary supplement designed to alleviate menopausal symptoms, particularly hot flashes and night sweats. So it claims anyway. The problem is there's next to no backing for the ingredients aside from their own customer surveys.
It is marketed as a natural alternative to hormone replacement therapy (HRT) and is popular among women seeking hormone-free solutions
- Primary Purpose A self funded trial demonstrated a reduction in the severity and frequency of these symptoms
- Key Ingredients Relizen is a proprietary blend called Sérélys, which is made from highly purified pollen extracts from Swedish flowers.
- Potential benefits: By reducing night sweats, Relizen can help improve overall sleep quality
- Format: Capsules
- Target Audience: Women experiencing these common menopausal symptoms potentially could benefit from Relizen's non-hormonal approach to relief.
Pros and Cons of Relizen Bonafide.
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Pros |
Cons |
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Non-Hormonal: Provides relief from hot flashes and night sweats without using hormones |
Not FDA-Regulated: Supplements, including Relizen, are not regulated by the FDA for safety or efficacy. |
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Clinically Tested: Multiple clinical studies support its effectiveness in reducing menopausal symptoms |
Some users report mild side effects like headaches and diarrhea |
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Made from purified pollen extracts from Swedish flowers |
May not work for everyone, and results can take up to two months to notice |
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Endorsed by over many doctors in the US. |
Can be expensive compared to similar products on the |
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Free from common allergens, making it suitable for most |
Some reviews mention a lack of independent clinical testing and transparency |
What Makes Relizen Bonafide Unique?
Unlike many menopause supplements, Relizen does not contain hormones or hormone-mimicking compounds. It works by regulating body temperature naturally. Containing a proprietary blend called Sérélys, made from highly purified pollen extracts from Swedish flowers. This natural ingredient is unique and has had no high quality clinical trials to test for its effectiveness meaning there's not really much positive to say about Relizen.
Overall benefits of Relizen Bonafide.
Clinical studies have shown that Relizen significantly reduces the frequency and severity of hot flashes and night sweats, providing relief from these common menopausal symptoms. Relizen is a non-hormonal supplement, making it a safe alternative for women who cannot or prefer not to use hormone replacement therapy (HRT).
Who Should Use Relizen Bonafide?
Relizen Bonafide is designed to support women experiencing menopausal symptoms, particularly hot flashes and night sweats. Those whose sleep is disrupted by night sweats and temperature fluctuations can benefit from improved sleep quality with Relizen
Price Comparison: Femarelle vs. Relizen Bonafide.
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Product |
Price per Bottle (56 Capsules/60 Tablets) |
Subscription Options |
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Femarelle |
$30.10 - $34.99 |
Not available |
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Relizen Bonafide |
$55.80 - $62.00 |
Monthly: $42 / Quarterly: $114 |
Final Thoughts
Femarelle and Relizen Bonafide offer unique solutions, but neither are particularly great.
Femarelle contains ingredients that have undergone limited clinical studies suggesting benefits for bone density and a potential reduction in the risk of osteoporosis. It offers various supplements tailored to different stages of menopause and different age groups. Despite a reported 73% success rate in reducing night sweats and hot flashes—which is above average—it does not provide the multi-spectral approach found in it's competitors, and as it's ingredient isn't unique it's hard to recommend in general, although we would recommend it more than Bonafide.
Relizen Bonafide, on the other hand, is a natural, non-hormonal alternative specifically designed for hot flashes and night sweats. Made from purified pollen extracts from Swedish flowers, it is considered well-tolerated with minimal side effects. However, the evidence really isn't well backed, and it's quite expensive.