KaraMD Comfort Guard x24 Has A Simple Formula But Could Use Higher Doses
Comfort Guard x24 isn't a bad idea, Boswellia is a good ingredient and it's correctly dosed, but the curcumin is under dosed as is the ginger extract, meaning that KaraMD comfort guard x24 is functionally a very overpriced Boswellia pill. That's not to say that the curcumin is such a low dose that it will do nothing at all to reduce inflammation, but it definitely is well below ideal. Curcumin is the active ingredient in Turmeric, and typically it's dosed at 500mg and up in the trials where it has been shown to be effective. [1]
Now, you'd initially think that having 150mg of it and 1050mg of Turmeric simultaneously would give you enough, but Turmeric typically only contains 3% curcumin. [2] Sometimes it can get as high as 20%, so if we're being generous you could have about 350mg, but that still isn't ideal. The ginger extract in comfort guard x24 also has a similar issue, but it's even more exacerbated as the amount here is about 30 times to little as it's not. There is a work around for this with using a specific extract highly dosed with hydroxymethoxyphenyl [3], but comfort guard x24 doesn't do that.
The customer reviews of comfort guard x24 are mixed, not terrible, so it is potentially due simply to Boswellia extract present, but it could also be slightly improved by the turmeric decreasing inflammation. There are some reviews that show they honor their money back guarantee, which is a positive though.
But, when we compare comfort guard x24 to the number one joint supplement on the market at the moment, it doesn't look like a great value proposition. FlexAgain for example contains all of these ingredients in their proper dosage, and 8 more. In terms of active ingredients this totals almost 4 times as much for $25 more. Or alternatively a simple boswellia supplement which you can pick up for half the price we'd say that you're better off with one of these options.
Comfort Guard x24 Pros And Cons
Comfort Guard x24 Side Effects
A few people mentioned gastric distress, this isn't incredibly abnormal as a few people do have a sensitivity to turmeric. Even though for most adults it will improve digestion, but as with all supplements there are some people who will suffer with stomach discomfort.
Comfort Guard x24 Ingredients
Turmeric Root Powder 1050mg - Turmeric has been shown to have notable anti inflammatory properties, and there have been multiple trials which have shown relatively consistent results. It's been shown to be effective at helping with multiple chronic diseases that cause acute inflammation and muscle pain. [4] It's generally beneficial for digestive support, although as mentioned some people don't tolerate it well. This is relatively uncommon though for the natural supplement.
Boswellia Serrata 200mg - Boswellia Serrata is a common ingredient in joint pain supplements. There are a lot of trials to back it's use and we generally consider it to be a good ingredient for comfort guard x24. [5] The only catch is it's a relatively cheap ingredient for supplements focused on chronic pain and most budget supplements contain it and other effectively dosed ingredients.
Curcumin 150mg - Curcumin is a fantastic anti inflammatory and one of the most well backed for any natural pain relief supplement. The problem is that as we mentioned in the intro it's generally dosed a bit higher. It's actually be shown to be as effective as many inflammatory medications. [6] Treatment groups have been shown to have a reduction in medical markers of inflammation, [7] [8] [9] as well as self reported joint stiffness and improvements to painful joints in general. Although a few studies have shown only shown only pain reduction and no improvement to joint stiffness. [10] That said, there's still more than enough evidence to shown that it's effective, with many trial participants continuing to take the supplements after the trails and even reducing other treatments. Comfort Guard X24 made a good decision with this inclusion. Just they could've included more. Like turmeric it can cause stomach discomfort in some.
Ginger Root Powder 100mg - Ginger does contain anti inflammatory compounds known as gingerols, typically speaking galangal contains these in higher doses and the extracts that work at doses lower than 3 grams, which is raw ginger roots effective range [10] are generally made of a combination of the two. Even then the lowest dosed effective clinical trials were at 255mg of the extract. [3] As a result this is far to under dosed to be within the effective range for anti inflammatory effects and pain relief.
References
1 - https://www.nccih.nih.gov/health/turmeric
2 - https://pubmed.ncbi.nlm.nih.gov/17044766/
3 - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5660798/
4 - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7522354/
5 - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3309643/
6 - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5664031/
7 - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3591524/
8 - https://pubmed.ncbi.nlm.nih.gov/20657536
9 - https://pubmed.ncbi.nlm.nih.gov/24853120
10 - https://pubmed.ncbi.nlm.nih.gov/24853120
11 - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7754412/